Toward Systems Biology

May 30 - 31, June 1, 2011


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Predicting Emergent Behavior in Cardiac Tissue: A Grand Challenge

Cardiac disorders such as tachycardia and fibrillation are spatial-temporal behaviors of cardiac-cell networks, which correspond to spiral-voltage-wave build-up and break-up respectively, and which emerge in certain conditions. To understand and predict these conditions, mathematical, mostly differential equations, models of cardiac cells have been constructed over the years. They range from 4 to 67 variables and from 27 to 400 associated parameters. The main tool for the analysis of such models is still plain simulation. In this talk I will address the challenges and opportunities associated with the techniques that go beyond simulation, such as model checking and parameter-range identification.

Radu Grosu, Stony Brook University